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A tandem Petasis-Ugi multi component condensation reaction: solution phase synthesis of six dimensional libraries |
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| Authors: | David E Portlock Ryszard OstaszewskiDinabandhu Naskar Laura West |
| Institution: | a Combinatorial Chemistry Section, Procter & Gamble Pharmaceuticals Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA b Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland c Chembiotek Research International, Block BN, Sector-V, Salt Lake City, Calcutta 700 091, India |
| Abstract: | Amino acids with three points of diversity generated from the Petasis boronic acid-Mannich reaction can be used as one of the four components of the Ugi condensation to prepare six dimensional libraries of dipeptide amides. |
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