Titanium-mediated synthesis of bicyclic cyclopropylamines from unsaturated nitriles |
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| Authors: | Christophe LarochePhilippe Bertus Jan Szymoniak |
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| Institution: | UMR 6519-Réactions Sélectives et Applications, CNRS-Université de Reims Champagne-Ardenne, UFR Sciences, BP 1039, 51687 Reims Cedex 2, France |
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| Abstract: | Here we report an easy synthesis of bicyclic primary cyclopropylamines directly from unsaturated nitriles. The described reaction involves Ti(II)-mediated intramolecular coupling of alkene and nitrile moieties. |
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| Keywords: | bicyclic compounds cyclizations cyclopropanes nitriles titanium |
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