A versatile and efficient synthesis of (2S)-2-(hydroxymethyl)-N-Boc-2,3-dihydro-4-pyridone |
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| Authors: | A Shashidhar KumarB Haritha B Venkateswara Rao |
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| Institution: | Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500007, India |
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| Abstract: | A versatile and efficient method for the preparation of (2S)-2-(hydroxymethyl)-N-Boc-2,3-dihydro-4-pyridone from l-(−)-phenylalanine 2 utilising the aromatic system as a masked β-keto aldehyde was developed. The key step in the sequence is an intramolecular cyclisation of 6 to give 2,3-dihydropyridin-4-ones. |
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