Synthesis of a potential reactivator of acetylcholinesterase—1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)propane dibromide |
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| Institution: | Purkyně Military Medical Academy, Department of Toxicology, PO Box 35/T, 500 01, Hradec Králové, Czech Republic |
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| Abstract: | Two methods for the synthesis of a new unsymmetric bispyridinium oxime-1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)propane dibromide are described. In vitro efficacy of this new oxime to reactivate sarin-inhibited acetylcholinesterase has been evaluated. |
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| Keywords: | acetylcholinesterase oxime reactivation sarin synthesis |
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