A novel class of bidentate ligands with a conformationally flexible biphenyl unit built into a planar chiral [2.2]paracyclophane backbone |
| |
Authors: | VI Rozenberg DYu AntonovRP Zhuravsky EV VorontsovZA Starikova |
| |
Institution: | A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991 Moscow, Russia |
| |
Abstract: | We report the synthesis of a novel class of planar chiral bidentate aryl2.2]paracyclophane ligands. For the first time in the 2.2]paracyclophanyl series the Pd-catalyzed Suzuki cross-coupling was employed for the formation of the arylparacyclophanyl skeleton. From the two possible approaches: (a) cross-coupling of 2.2]paracyalophanylboronic acids with aryl halides; (b) cross-coupling of 2.2]paracyclophanyl halides with arylboronic acids, the latter was found to be more efficient. This approach was successfully used for the synthesis of a wide range of aryl2.2]paracyclophanes with different types of substitution patterns (ortho-, pseudo-ortho- or pseudo-gem-arrangement of the functionally-substituted aryl fragment with respect to the substituent in the paracyclophane ring). |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |