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Synthesis and antitumor activity of DNA binding cationic porphyrin-platinum(II) complexes |
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| Authors: | Rita SongYeong-Sang Kim Chong Ock LeeYoun Soo Sohn |
| Affiliation: | a Division of Life Sciences, Korea Institute of Science and Technology, Seoul 136-791, South Korea b Department of Chemistry, Ewha Womans University, Seoul 120-750, South Korea c Department of Chemistry, Yonsei University, Seoul 120-749, South Korea d Pharmaceutical Screening Laboratory, Korea Research Institute of Chemical Technology, Taejon 305-343, South Korea |
| Abstract: | A new series of DNA binding 5,10,15-tri(N-methyl-4-pyridiniumyl)porphyrin (TrisMPyP)-platinum(II) conjugates was synthesized, in which different spacer ligands were used for appropriate coordination to platinum(II) complexes. Compound 9b exhibited in vivo antitumor activity (T/C%, 294) superior to cisplatin (T/C%, 184) against the leukemia L1210 cell line. |
| Keywords: | porphyrin antitumor agent DNA binding platinum(II) |
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