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Enantiospecific synthesis of an indolizidine alkaloid, (+)-ipalbidine |
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| Authors: | Toshio Honda Hidenori NamikiHiromasa Nagase Hirotake Mizutani |
| Institution: | Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa, Tokyo 142-8501, Japan |
| Abstract: | Enantiospecific total synthesis of an indolizidine alkaloid, ipalbidine, was achieved starting from (−)-pyroglutamic acid by employing an intramolecular McMurry coupling reaction with a low-valent titanium, as a key step. |
| Keywords: | (+)-ipalbidine McMurry coupling indolizidine alkaloid ring-closing metathesis chiral synthesis |
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