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A novel TMSI-mediated synthesis of Hantzsch 1,4-dihydropyridines at ambient temperature |
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| Authors: | Gowravaram Sabitha GSKiran Kumar ReddyChSrinivas Reddy JS Yadav |
| Institution: | Organic Chemical Sciences, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | The synthesis of various substituted Hantzsch 1,4-dihydropyridines has been achieved using the classical Hantzsch procedure and modified Hantzsch conditions for the first time at room temperature in the presence of iodotrimethylsilane (TMSI) generated in situ in CH3CN, in excellent yields. |
| Keywords: | TMSI Hantzsch 1 4-dihydropyridines one-pot condensation ambient temperature |
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