A versatile one-pot procedure to phosphate monoesters and pyrophosphates using di(p-methoxybenzyl)-N,N-diisopropylphosphoramidite |
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| Authors: | van der Heden van Noort Gerbrand J Verhagen Carlo P van der Horst Maarten G Overkleeft Herman S van der Marel Gijsbert A Filippov Dmitri V |
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| Institution: | Leiden Institute of Chemistry, Leiden Unversity, PO Box 9502, 2300 RA Leiden, The Netherlands. |
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| Abstract: | A one-pot procedure for the preparation of phosphoramidates, phosphorothioates, pyrophosphates, phosphodiesters, and phosphofluoridates has been devised using di(p-methoxybenzyl)-N,N-diisopropylphosphoramidite as the common phosphitylating reagent. |
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