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Synthesis of 2-oxazolines mediated by N,N′-diisopropylcarbodiimide |
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| Authors: | Stefano Crosignani Abigail C. Young Bruno Linclau |
| Affiliation: | aCombinatorial Centre of Excellence, School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK |
| Abstract: | N-(β-Hydroxy)amides can be cyclised by reaction with diisopropylcarbodiimide (DIC) to give the corresponding 2-oxazolines in high yields. The reaction requires only very mild Lewis-acid catalysis (5 mol % Cu(OTf)2) and can be accomplished with simple heating, or in very short reaction times under microwave irradiation. |
| Keywords: | 2-Oxazoline Isourea Lewis acid Microwave irradiation Carbodiimide |
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