Measurement of one-bond heteronuclear dipolar coupling contributions for amine and diastereotopic methylene protons |
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| Authors: | Kövér Katalin E Fehér Krisztina |
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| Institution: | Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1, P.O. Box 21, H-4010 Debrecen, Hungary. kover@tigris.unideb.hu |
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| Abstract: | One-bond heteronuclear and two-bond homonuclear residual dipolar couplings measured at methylene or amine sites can be utilized as long-range constraints in structure determination of molecules as well as to facilitate characterization of local conformation by stereospecific assignment of diastereotopic protons. We present two J-modulated HMQC type experiments to measure the one-bond heteronuclear dipolar coupling contributions of geminal protons individually. In addition two-bond homonuclear residual dipolar couplings between the diastereotopic protons are also obtained. |
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| Keywords: | Residual dipolar coupling constant One-bond heteronuclear coupling constant Homonuclear two-bond coupling constant Amine/diastereotopic methylene protons J-modulation HMQC |
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