Efficient and facile formation of two-component nanoparticles via aromatic moiety directed self-assembly |
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Authors: | Wang Weiping Chau Ying |
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Institution: | Department of Chemical and Biomolecular Engineering, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China. |
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Abstract: | Here we present a two-component self-assembling system employing the interaction of aromatic groups (Fmoc) to construct nanoparticles. Spherical particles of around 70 nm were formed spontaneously by a simple trigonal Fmoc-conjugate, which were then stabilized by Fmoc-dipeptides at physiological pH in aqueous solution. These novel particles, being well-tolerated by cells, capable of encapsulating hydrophobic compounds, and readily decorated by short peptides, are promising carriers for drug delivery. |
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