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Synthesis of new enantiomerically pure N-methyl-N-arylsulfonyl-α-aminonitriles from amino acids |
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| Authors: | Najeh Tka Jamil Kraïem Yakdhane Kacem Amira Hajri Bchir Ben Hassine |
| Institution: | aLaboratoire de Synthèse Organique Asymétrique et Catalyse Homogène (01 UR 1201), Faculté des Sciences de Monastir, Avenue de l'Environnement, 5019 Monastir, Tunisia |
| Abstract: | New enantiomerically pure N-methyl-N-arylsulfonyl-α-aminonitriles were prepared starting from the corresponding α-amino acids by way of N-methyl-N-arylsulfonyl-α-amino amides. The key step of this sequence consists of the dehydration of amides by thionyl chloride which proceeded without a significant racemization. Enantiomeric purity of nitriles was determined by HPLC analysis. |
| Keywords: | α -Amino acids N-Methyl-N-arylsulfonyl-α -aminoamides Thionyl chloride N-Methyl-N-arylsulfonyl-α -aminonitrilesMots-clé s: Acides α -aminé s N-methyl-N-aryksulfonyl-α -aminoamides Chlorure de thionyle N-methyl-N-arylsulfonyl-α -aminonitriles |
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