Cytotoxic metabolites of <Emphasis Type="Italic">Streptimonospora salina</Emphasis> |
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| Authors: | Wei-Hong Liu Ming-Gang Li Yi-Qing Li Jiang-Yuan Zhao Zhang-Gui Ding Pei-Wen Yang Xiao-Long Cui Meng-Liang Wen |
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| Institution: | (1) Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, Yunnan, 650091, China;(2) Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan University, Kunming, Yunnan, 650091, China |
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| Abstract: | Streptimonospora salina gen. nov., sp. nov. was found to produce three phenoxazinone antibiotics, 2-amino-3H-phenoxazin-3-one (1), 2-methylamino-3H-phenoxazin-3-one (2), 2-acetylamino-3H-phenoxazin-3-one (3), and one phenazine antibiotic, phenazine-1-carboxylic acid (4). The chemical structures of the compounds
were determined using 1D and 2D NMR spectrometry and electrospray mass spectrometry (ESMS). Compounds 1-4 exhibited modest
cytotoxicity against a human renal carcinoma cell line ACHN with IC50 values of 35.4, 12.4, 65.4, and 82.9 μM, respectively. Compound 2 was discovered for the first time from a biological origin.
Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 405–406, July–August, 2008 |
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| Keywords: | phenoxazinoes Streptimonospora salina gen nov sp nov cytotoxic |
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