Influence of the preparation method on the physicochemical properties of econazole-β-cyclodextrin complexes |
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| Authors: | Ali H Al-Marzouqi Ayser Solieman Ihsan Shehadi Abdu Adem |
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| Institution: | (1) Department of Chemical & Petroleum Engineering, UAE University, P.O. Box: 17555, Al-Ain, UAE;(2) Department of Chemistry, UAE University, P.O. Box: 17555, Al-Ain, UAE;(3) Department of Pharmacology and Therapeutics, UAE University, P.O. Box: 17666, Al-Ain, UAE |
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| Abstract: | Econazole (C18H15Cl3N2O) is one of the common antifungal agents whose poor aqueous solubility restricts its use for the treatment of oropharyngeal
candidiasis, which is the first symptom of HIV infection. Therefore, the aim of the current study was to investigate the effect
of different preparation methods (i.e. kneading, coevaporation, sealed-heating, and supercritical carbon dioxide (SC CO2)) for obtaining solid inclusion complexes between β-cyclodextrin and econazole. The physico-chemical properties of the different products were characterized by differential
scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffractometry (PXRD). For the
complexes prepared by the SC CO2 method, the effects of temperature and pressure have also been investigated and related to the solubility of econazole in
SC CO2. Results suggested the validity of the SC CO2 method for preparing solid complexes between cyclodextrins and econazole, avoiding the use of organic solvents and problems
of their complete removal. Moreover, temperature played a major role in promoting drug-carrier interactions, whereas pressure
had limited effects. |
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| Keywords: | Cyclodextrin Econazole Inclusion complex Supercritical carbon dioxide |
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