4-Hydroxy-2-quinolones 139. Synthesis,structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-<Emphasis Type="Italic">a</Emphasis>]pyrimidine-3-carboxylic acids |
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Authors: | I V Ukrainets N L Bereznyakova I A Turaibei |
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Institution: | (1) National University of Pharmacy, Kharkiv, 61002, Ukraine;(2) Kharkiv Medical Academy of Postgraduate Education, Kharkiv, 61176, Ukraine |
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Abstract: | Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral
agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results
are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 61–77, January, 2008. |
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Keywords: | amides 2-hydroxy-4-oxo-4H-pyrido[1 2-a]pyrimidines herpes coronavirus antiviral activity X-ray structural analysis |
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