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Synthesis of a hemifluorinated amphiphile designed for self-assembly and two-dimensional crystallization of membrane protein |
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| Authors: | Julien Dauvergne Catherine Vénien-Bryan |
| Institution: | a Université d’Avignon et des pays du vaucluse, laboratoire de chimie bioorganique et des systèmes moléculaires vectoriels, 33 rue Louis Pasteur, F-84000 Avignon, France b Laboratory of Molecular Biophysics, University of Oxford, South Park Road, OX1 3QU Oxford, UK |
| Abstract: | The work reported herein deals with the synthesis and the preliminary physical-chemical analysis of new hemifluorinated surfactant made up of one fluorinated chain linked to a tricarboxylic acid polar head which is able to complex a Ni atom and should favor the two-dimensional crystallization of membrane proteins. Such a compound forms a Langmuir film which is a fluid at 20 °C and not perturbed by the presence of hydrocarbon detergent in aqueous solution. |
| Keywords: | Hemifluorinated surfactants Langmuir film Membrane proteins Nickel complexation 2D proteins crystallization |
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