Synthesis of (R)-quinuclidine-2-carboxylic acid in enantiomerically pure form |
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Authors: | Pablo Etayo,José A. Gá lvez |
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Affiliation: | Departamento de Química Orgánica, Instituto de Ciencia de Materiales de Aragón, Instituto Universitario de Catálisis Homogénea, Universidad de Zaragoza-CSIC, E-50009 Zaragoza, Spain |
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Abstract: | Enantiomerically pure (R)-quinuclidine-2-carboxylic acid has been prepared by following two related 7 step synthetic routes in 16% and 19% overall yield, respectively, from a 1,2,4-trisubstituted piperidine that is easily prepared from inexpensive d-mannitol. |
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Keywords: | Azabicyclo[2.2.2]octane Intramolecular cyclisations Piperidines Stereoselective synthesis |
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