PhSO2SCF2H: A Shelf‐Stable,Easily Scalable Reagent for Radical Difluoromethylthiolation |
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| Authors: | Dr. Dianhu Zhu Dr. Xinxin Shao Xin Hong Prof. Dr. Long Lu Prof. Dr. Qilong Shen |
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| Affiliation: | Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China |
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| Abstract: | A new shelf‐stable and easily scalable difluoromethylthiolating reagent S‐(difluoromethyl) benzenesulfonothioate (PhSO2SCF2H) was developed. PhSO2SCF2H is a powerful reagent for radical difluoromethylthiolation of aryl and alkyl boronic acids, decarboxylative difluoromethylthiolation of aliphatic acids, and a phenylsulfonyl‐difluoromethylthio difunctionalization of alkenes under mild reaction conditions. |
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| Keywords: | decarboxylation fluorine radicals reaction mechanisms synthetic methods |
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