Asymmetric addition of phenylacetylene to aldehydes catalyzed by complex of O‐sulfonyl camphor derivatives and titanium |
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| Authors: | Dong‐Sheng Lee Chang‐Weu Gau Yu‐Yang Chen Ta‐Jung Lu |
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| Institution: | Department of Chemistry, National Chung‐Hsing University, Taichung, Taiwan |
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| Abstract: | Several novel ligands that are based on the camphor skeleton or contain the O‐sulfonyl group were synthesized and used in the asymmetric addition of phenylacetylene to aldehydes. This enantioselective reaction afforded chiral propargylic alcohols in high yields and with good to excellent levels of enantiopurity (up to 99% enantiomeric excess). Copyright © 2016 John Wiley & Sons, Ltd. |
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| Keywords: | asymmetric alkynylation O‐sulfonyl ligand propargylic alcohol titanium catalysis |
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