Nickel‐catalyzed Buchwald–Hartwig amination of pyrimidin‐2‐yl tosylates with indole,benzimidazole and 1,2,4‐triazole |
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| Authors: | Hai‐Peng Gong Zheng‐Jun Quan Xi‐Cun Wang |
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| Affiliation: | 1. Key Laboratory of Eco‐Environment‐Related Polymer Materials, Ministry of Education of China, Gansu, People's Republic of China;2. Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Gansu, People's Republic of China;3. College of Natural Science, Gansu Agricultural University, Lanzhou, Gansu, People's Republic of China |
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| Abstract: | Nickel‐catalyzed Buchwald–Hartwig amination of pyrimidin‐2‐yl tosylates with indole and benzimidazole was achieved using Ni(dppp)Cl2 as catalyst, yielding a variety of novel C2‐substituted pyrimidine derivatives in good yields. This reaction proved to be tolerant of various pyrimidin‐2‐yl tosylates bearing either electron‐donating or electron‐withdrawing groups as well as nucleophiles including indole, benzimidazole and 1,2,4‐triazole. Copyright © 2016 John Wiley & Sons, Ltd. |
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| Keywords: | pyrimidin‐2‐yl tosylates Buchwald– Hartwig amination indole Ni catalyst tetra‐substituted pyrimidine derivatives |
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