Combining Organocatalysis and Lanthanide Catalysis: A Sequential One‐Pot Quadruple Reaction Sequence/Hetero‐Diels–Alder Asymmetric Synthesis of Functionalized Tricycles |
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| Authors: | Dr. Simon Dochain M. Sc. Fabrizio Vetica Dr. Rakesh Puttreddy Prof. Dr. Kari Rissanen Prof. Dr. Dieter Enders |
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| Affiliation: | 1. Institute of Organic Chemistry, RWTH Aachen University, Aachen, Germany;2. Department of Chemistry, Nanoscience Center, University of Jyvaskyla, Finland |
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| Abstract: | A stereoselective one‐pot synthesis of functionalized complex tricyclic polyethers has been achieved using the combination of secondary amine and lanthanide catalysis. This one‐pot quadruple reaction/Hetero‐Diels–Alder sequence gave good yields (per step) as well as excellent diastereo‐ and enantioselectivities. Furthermore, the particular combination of lanthanide complexes with organocatalysis is one of the first examples described for sequential catalysis. |
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| Keywords: | asymmetric catalysis heterocycles lanthanides organocatalysis synthetic methods |
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