One‐pot,four‐component synthesis of 1,3,4‐oxadiazole derivatives containing a ferrocene unit and their antimicrobial activity |
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| Authors: | Ali Reza Kazemizadeh Nahid Shajari Reza Shapouri Neda Adibpour Reza Teimuri‐Mofrad Parisa Dinmohammadi |
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| Affiliation: | 1. Research Laboratory of MCR, Department of Chemistry, Zanjan Branch, Islamic Azad University, Zanjan, Iran;2. Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran;3. Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran;4. Organic Synthesis Research Laboratory, Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran |
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| Abstract: | A four‐component reaction between aromatic carboxylic acids, (N‐isocyanimino)triphenylphosphorane, ferrocenecarbaldehyde and dibenzylamine is reported. This approach is an efficient, simple and high‐yield procedure for the synthesis of 1,3,4‐oxadiazole derivatives containing a ferrocene unit. The antimicrobial activities of the products were investigated against Staphylococcus aureus and Pseudomonas aeruginosa in in vitro and in vivo assays. Copyright © 2015 John Wiley & Sons, Ltd. |
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| Keywords: | multicomponent reaction ferrocene 1,3,4‐oxadiazole (N‐isocyanimino)triphenylphosphorane Staphylococcus aureus Pseudomonas aeruginosa |
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