α-氨基酸乙酯卤根合铂(II)的合成和构型研究

Synthesis and configuration of halogenoethyl-aminoacidato Pt(II) complexes.

Sixteen new halogenoethylaminoacidato Pt(II) complexes were synthesized and characterized, of which eightiodo complexes (PtA2I2) (A = DL-a-AlaOEt, L-a-alaOEt, DL-a-PheOEt, L-a-PheOEt, DI-A-AspOEt, L-a-AspOEt, DL-a-SerOEt and L-a-Lys OEt), four chloro compounds (PtA2Cl2)(A = DL-a-PheOEt, DL-a-AspOEt, L-a-Asp OEt) and (DL-a-PheHOEt)2(PtCl4) were obtained by reaction of K2 (PtX4)(X = I^-, Cl^-) with the corresponding ethylaminoacidates in water. The other chlorethylaminoacidato Pt(II) complexes (PtA2Cl2) (A = DL-a-AlaOEt, L-a-AlaOEt, L-a-PheOEt, DL-a-Ser OEt) were synthesized in acetone by exchange reaction of the corresponding iodo complexes with AgCl in order to avoid hydrolysis of the ethyl aminoacidates. Molar conductivity determination showed that all the Pt(II) complexes obtained were neutral molecules with the exception of (DL-a-PheHOEt)2(PtCl4) which existed as an anion. As shown by diole moment determination and modified thiourea reaction, iodo complexes 1-7 and some of the chloro complexes (PtA2Cl2) (A = DL-a-alaOEt, D-a-AlaOEt, DL-a-SerOEt) were of cis-configuration and the other chloro complexes were of trans-configuration.