| Saframycins 及Ecteinascidins化合物的合成研究进展 |
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| 引用本文： | 王晔,唐叶峰,刘站柱,陈世智,梁晓天.Saframycins 及Ecteinascidins化合物的合成研究进展[J].有机化学,2005,25(1):42-52. |
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| 作者姓名： | 王晔 唐叶峰 刘站柱 陈世智 梁晓天 |
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| 作者单位： | 中国医学科学院中国协和医科大学药物研究所,北京,100050 |
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| 基金项目： | 国家自然科学基金(No. 30371681)，北京市自然科学基金(No. 7042041)资助项目. |
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| 摘 要： | 综述了两类双四氢异喹啉生物碱Saframycins和Ecteinascidins的合成研究进展. 分析了各合成路线的关键步骤, 部分讨论了各方法的优缺点, 并对其生物合成和作用机理作了简单介绍.
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| 关 键 词： | 双四氢异喹啉生物碱 saframycin ecteinascidin phthalascidin 合成 |
| 收稿时间： | 2004-3-1 |
| 修稿时间： | 2004年3月1日 |
Synthetic Progress in Saframycins and Ecteinascidins |
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| WANG,Ye TANG,Ye-Feng LIU,Zhan-Zhu CHEN,Shi-Zhi LIANG,Xiao-Tian.Synthetic Progress in Saframycins and Ecteinascidins[J].Chinese Journal of Organic Chemistry,2005,25(1):42-52. |
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| Authors: | WANG Ye TANG Ye-Feng LIU Zhan-Zhu CHEN Shi-Zhi LIANG Xiao-Tian |
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| Institution: | (Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing 100050) |
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| Abstract: | The tetrahydroisoquinoline antitumor antibiotics have been studied thoroughly over the past 30 years. This paper reviews the synthetic progress in two kinds of bis-tetrahydroisoquinoline alkaloids, safra- mycins and ecteinascidins. The key reaction of each synthetic route has been analyzed. Both applications and limitations of these approaches were discussed. Some views on the biosynthesis and mechanism of ac- tion were summarized too. |
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| Keywords: | bis-tetrahydroisoquinoline alkaloid saframycin ecteinascidin phthalascidin synthesis |
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