Institut für Organische Chemie und Biochemie der Universität Bonn,Gerhard-Domagk-Str. 1, D-5300, Bonn 1, BRD
Abstract:
Using Cp(Me)5Rh(bipy)C1]C1 (1) as redox catalyst for the continous NADH regeneration it was possible to perform an electrochemically driven enzymatic reduction of pyruvate to D-lactate catalyzed by D-LDH at a rate of 5 turnovers per hour. This is by a factor of 20 faster than the best results obtained until now. Current yields of 50 to 70 % may be obtained.