Ring-closing metathesis in the synthesis of BC ring-systems of taxol |
| |
Authors: | Ma Cong Schiltz Stéphanie Le Goff Xavier F Prunet Joëlle |
| |
Affiliation: | Laboratoire de Synthèse Organique, CNRS UMR 7652, Ecole Polytechnique, DCSO, Palaiseau Cedex, France. |
| |
Abstract: | BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail. |
| |
Keywords: | metathesis organic chemistry ruthenium synthesis taxol |
本文献已被 PubMed 等数据库收录! |
|