Ring-closing metathesis in the synthesis of BC ring-systems of taxol |
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| Authors: | Ma Cong Schiltz Stéphanie Le Goff Xavier F Prunet Joëlle |
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| Affiliation: | Laboratoire de Synthèse Organique, CNRS UMR 7652, Ecole Polytechnique, DCSO, Palaiseau Cedex, France. |
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| Abstract: | BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail. |
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| Keywords: | metathesis organic chemistry ruthenium synthesis taxol |
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