| 利用氢化物发生-冷阱捕集-原子吸收光谱联用技术测定雄黄染毒大鼠血中砷的含量 |
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| 引用本文： | 张颖花,高咏,霍韬光,姜泓,孙贵范.利用氢化物发生-冷阱捕集-原子吸收光谱联用技术测定雄黄染毒大鼠血中砷的含量[J].化学研究,2013(3):274-276. |
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| 作者姓名： | 张颖花 高咏 霍韬光 姜泓 孙贵范 |
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| 作者单位： | 中国医科大学公共卫生学院;沈阳市食品药品检验所;辽宁省砷生物学作用与砷中毒重点实验室 |
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| 基金项目： | 国家自然科学基金资助项目(81073144);中国博士后科学基金面上资助项目(2012M510848) |
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| 摘 要： | 采用氢化物发生-冷阱捕集-原子吸收光谱法(HG-CT-AAS)测定了雄黄染毒大鼠血中不同形态砷的含量.结果表明,雄黄在大鼠体内的代谢产物为无机砷、一甲基胂酸和二甲基胂酸,其中二甲基胂酸是主要代谢产物;3种形态砷的精密度、准确度、回收率及线性关系良好.
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| 关 键 词： | 雄黄 砷 氢化物发生-冷阱捕集-原子吸收光谱法 测定 |
Determination of arsenic species in blood of rats treated with realgar by hydride generation-cryogenic trapping-atomic absorption spectrophotometry |
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| ZHANG Ying-hua,GAO Yong,HUO Tao-guang,JIANG Hong,SUN Gui-fan.Determination of arsenic species in blood of rats treated with realgar by hydride generation-cryogenic trapping-atomic absorption spectrophotometry[J].Chemical Research,2013(3):274-276. |
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| Authors: | ZHANG Ying-hua GAO Yong HUO Tao-guang JIANG Hong SUN Gui-fan |
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| Institution: | 1,3(1.School of Public Health,China Medical University,Shenyang 110001,Liaoning,China; 2.Shenyang Institute for Food and Drug Control,Shenyang 110013,Liaoning,China; 3.Liaoning Key Laboratory of Arsenic Biological Effect and Arsenic Poisoning,Shenyang 110001,Liaoning,China) |
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| Abstract: | The content of arsenic species in the blood of rats treated with realgar was analyzed by means of automated hydride generation-cryogenic trapping-atomic absorption spectropho- tometry （HG-CT-AAS）. Results show that the metabolic products of realgar in the body of rats include inorganic arsenic, monomethyl arsenic acid and dimethyl arsenic acid, in which dimethyl arsenic acid is the predominant arsenic species. Besides, various arsenic species can be well separated and determined by established HG-CT-AAS method with a good precision, accu- racy, recovery and linearity. |
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| Keywords: | realgar arsenic species HG-CT-AAS determination |
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