| Study on Fmoc Solid-phase Synthesis and Activity of Thymosin α1 |
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| 引用本文： | HAN Xiang GU Jun YUAN Qing-Lan GAN Yi-Ru. Study on Fmoc Solid-phase Synthesis and Activity of Thymosin α1[J]. 有机化学, 2003, 23(Z1): 240-241 |
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| 作者姓名： | HAN Xiang GU Jun YUAN Qing-Lan GAN Yi-Ru |
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| 作者单位： | HAN Xiang（Department of Chemistry, Medical College of Chinese People' s Armed Police Forces, Tianjin 300162） GU Jun（Department of Chemistry, Medical College of Chinese People' s Armed Police Forces, Tianjin 300162） YUAN Qing-Lan（Department of Chemistry, Medical College of Chinese People' s Armed Police Forces, Tianjin 300162） GAN Yi-Ru（Department of Chemistry, Medical College of Chinese People' s Armed Police Forces, Tianjin 300162） |
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| 摘 要： | Thymosin α1 (Tα1), an immunologically polypeptide, [1] is highly acidic composed of 28 amino acid residues with acetylserine as the NH2 terminus. The MW of this peptide is 3108, with pI 4.2. There are many Asp and Glu in this molecule and the complete amino acid sequence of Tα1 is Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-IleThr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH. This peptide has potent biological activity and has been found to be 10～ 1000 times as active as thymosin F5. In this paper, a Tα1 has been synthe sized by a solid-phase method. Peptide synthesis was performed manually by the stepwise solid-phase method using the base-labile Fmoc group for protecting the α-amino acid. [2]
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Study on Fmoc Solid-phase Synthesis and Activity of Thymosin α1 |
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| HAN Xiang,GU Jun,YUAN Qing-Lan,GAN Yi-ru. Study on Fmoc Solid-phase Synthesis and Activity of Thymosin α1[J]. Chinese Journal of Organic Chemistry, 2003, 23(Z1): 240-241 |
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| Authors: | HAN Xiang GU Jun YUAN Qing-Lan GAN Yi-ru |
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