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Silica from rice husks employed as drug delivery for folic acid |
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| Authors: | Mercedes Salazar Hernández Carmen Salazar Hernández Alfredo Gutiérrez Fuentes Enrique Elorza Marcelino Carrera-Rodríguez María J Puy Alquiza |
| Institution: | 1. Departamento de Ingeniería en Minas, Metalurgia y Geología, División de Ingenierías Universidad de, Guanajuato, 3600, Mexico 2. UPIIG, Instituto Politécnico Nacional, 36275 Silao de la Victoria Gto, Guanajuato, Mexico 3. Departamento de Química, División de ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, 36050, Mexico |
| Abstract: | Silica was obtained from rice husk, this type of silica is also known as SiO2-rice, was investigated as drug delivery for the folic acid. The SiO2-rice was obtained from calcinations at 600 °C and its textural properties were compared with mesoporous silica (MS). The maximum folic acid adsorption on SiO2-rice was at the 18 % weight, while MS adsorbs 19 % weight. An important pH effect on the drug released was observed; both silicas released around 35 % of acid folic at pH 7, while at pH 3 only 3 % of the drug was released. Differential Thermal Analyzer analysis suggests that the folic acid was not crystallized into the porous of the silica; therefore, it is possible that the drug was trapped within the complex network of pores preventing their full release. However, the drug released for 400 μg of folic acid, a commercial dose, indicated that until 93 % of drug could be released for the silicas at pH of 5.5; a minor desorption was observed by commercial tablet. |
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