Direct asymmetric aldol reactions catalyzed by l-proline-2,4,6-trinitroanilide |
| |
| Authors: | Kosuke Sato Rumiko Shimazawa Kiyomi Kakiuchi |
| |
| Affiliation: | a Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), Nara 630-0192, Japan
b Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts, Kyoto 610-0395, Japan |
| |
| Abstract: | Direct aldol reactions of several aromatic aldehydes with ketones using l-proline-2,4,6-trinitroanilide catalyst 2d were conducted. Under optimized conditions, high enantioselectivity (99% ee), regioselectivity (up to 95:5), and diastereoselectivity (up to 98:2) were achieved. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
