| BENZODIAZEPINE RECEPTORS IN ISOLATED ADRENAL GLOMERULOSA CELLS |
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| 作者姓名： | 宋烈昌 周廷冲 |
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| 作者单位： | Institute of Basic Medical Sciences，Academy ot Military Medical Sciences，Beijing，Institute of Basic Medical Sciences，Academy ot Military Medical Sciences，Beijing |
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| 基金项目： | Project supported by the National Natural Science Foundation of China |
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| 摘 要： | In our experiments the isolated rat adrenal glomerulosa cells displayed perlpheral-type benzodiazepine receptors, which could bind to ~3H] PKl1195 with an apparent equilibrium dissociation constant (KD) of 9.4±2.8 nmol/L and a maximal binding capacity (B_(max)) of 5.6q-1.8 pmol/10~6 cells. The effects of five ligands: PKl1195, Ro5--4846, flunitrazepam, diazepam and clonazepam on aldosterone secretion responses of isolated glomerulosa cells to anglotensin Ⅱ or extracellular potassium ions were observed. The logarithm of EO_(50) for these ligands as stimulators was well correlated with the logarithm of their Ki value for ~3H] PK11195 binding, suggesting that the stimulative effects might be mediated by the benzodiazepine receptor in isolated glomerulosa cells.
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BENZODIAZEPINE RECEPTORS IN ISOLATED ADRENAL GLOMERULOSA CELLS |
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| SONG LIE-CHANG ZHOU TING-CHONG.BENZODIAZEPINE RECEPTORS IN ISOLATED ADRENAL GLOMERULOSA CELLS[J].Science in China(Chemistry),1989(4). |
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| Authors: | SONG LIE-CHANG ZHOU TING-CHONG |
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| Abstract: | |
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| Keywords: | adrenal glomerulosa cell aldosterone secretion benzodiazepine receptor |
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