Ruthenium(II)-catalyzed para-selective CH difluoroalkylation of aromatic aldehydes and ketones using transient directing groups |
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| Authors: | Yaohang Cheng Yuhang He Jie Zheng Hui Yang Jun Liu Guanghui An Guangming Li |
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| Institution: | 1. Key Laboratory of Functional Inorganic Material Chemistry (MOE), School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China;2. College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, China |
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| Abstract: | A Ru(II)-catalyzed para-difluoroalkylation of aromatic aldehydes and ketones with a transient directing group has been developed. It utilizes less expensive ruthenium catalysts and allows facile access to challenging difluoroalkylated aldehydes. The mechanism studies suggest that the distinct coordination mode of ruthenium complex with imine moieties is responsible for para-selectivity. |
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| Keywords: | Difluoroalkylation Ruthenium catalysis |
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