Nonlinear optical metal-organic frameworks for ratiometric temperature sensing in physiological range |
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| Authors: | Yating Wan Yuanjing Cui Yu Yang Guodong Qian |
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| Institution: | State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | The precise and real-time sensing of the temperature within the physiological range is of great significance in biology and medicine. Here, a Zn-based metal-organic framework (MOF) named Zn-TCOMA is synthesized with good SHG performance due to its unique structure of the ligand and 3D frameworks. By encapsulating the two-photon fluorescent dye DMASE into the pores of Zn-TCOMA, the composite Zn-TCOMA?DMASE is obtained and simultaneously exhibits SHG response and two-photon fluorescence. Utilizing the intensity ratio between two-photon fluorescence of DMASE and SHG signal of Zn-TCOMA, Zn-TCOMA?DMASE exhibits ratiometric temperature sensing property at physiological temperature region of 20～60 °C with high sensitivity. This MOF thermometer also shows excellent repeatability, good biocompatibility, and high temperature resolution of 0.018 °C, opening a new avenue to develop diverse optical thermometric or thermographic applications in biotechnology or other areas. |
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| Keywords: | Ratiometric thermometer Nonlinear optic Metal-organic framework Physiological temperature Two-photon excited fluorescence |
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