A mitochondrial-targeted ratiometric probe for detecting intracellular H2S with high photostability |
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| Authors: | Dandan Bu Yuying Wang Na Wu Wei Feng Donghui Wei Zhanxian Li Mingming Yu |
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| Institution: | 1. Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China;2. Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Institutes of Biomedical Sciences & Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200433, China |
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| Abstract: | Based on 4-bromo-1,8-naphthalic anhydride, one novel ratiometric fluorescence H2S-probe (IDNA) was designed and synthesized. Further studies indicate that IDNA can sensitively recognize H2S (detection limit of 7 μmol/L) with good selectivity and anti-interference ability. In addition, IDNA has satisfactory photostability in HeLa cells, ability of mitochondrial co-localization, and can be utilized in fluorescence imaging of H2S. |
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| Keywords: | Ratiometric Mitochondrial localization Fluorescent probe Biological imaging |
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