Manganese catalyzed asymmetric transfer hydrogenation of ketones |
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| Authors: | Guang-Ya Zhang Sun-Hong Ruan Yan-Yun Li Jing-Xing Gao |
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| Institution: | Department of Chemistry, College of Chemistry and Chemical Engineering, National Engineering Laboratory for Green Chemical Production of Alcohols-Ethers-Esters, Xiamen University, Xiamen 361005, China |
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| Abstract: | The asymmetric transfer hydrogenation (ATH) of a wide range of ketones catalyzed by manganese complex as well as chiral PxNy-type ligand under mild conditions was investigated. Using 2-propanol as hydrogen source, various ketones could be enantioselectively hydrogenated by combining cheap, readily available MnBr(CO)5] with chiral, 22-membered macrocyclic ligand (R,R,R',R')-CyP2N4 (L5) with 2 mol% of catalyst loading, affording highly valuable chiral alcohols with up to 95% ee. |
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| Keywords: | Asymmetric catalysis Manganese Ketones Macrocyclic ligand Asymmetric transfer hydrogenation |
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