Samarium(II) iodide-mediated intramolecular conjugate additions of alpha,beta-unsaturated lactones |
| |
Authors: | Molander Gary A St Jean David J |
| |
Institution: | Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323, USA. gmolandr@sas.upenn.edu |
| |
Abstract: | Samarium(II) iodide, in the presence of catalytic amounts of nickel(II) iodide, has been used to promote intramolecular conjugate additions of alkyl halides onto alpha,beta-unsaturated lactones. This process has been shown to be applicable to a number of alpha,beta-unsaturated lactones, including tetrasubstituted olefins, and has been demonstrated to be quite general for the formation of saturated bicyclic and tricyclic lactones. The method presented herein provides a mild, efficient process to form structurally complex lactones from simple precursors. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|