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罂粟花粉十三肽类似物的合成及其结构与抗肿瘤活性关系研究
引用本文:许家喜,金声. 罂粟花粉十三肽类似物的合成及其结构与抗肿瘤活性关系研究[J]. 高等学校化学学报, 1999, 20(5): 722-726
作者姓名:许家喜  金声
作者单位:北京大学化学与分子工程学院, 北京 100871
摘    要:罂粟花粉十三肽对人肝癌和人乳腺癌肿瘤细胞具有明显的抑制作用,以其为先导化合物,设计并合成了5个类似物和5个片段,结合CD谱测定的二级结构及它们对人肝癌和人乳腺癌肿瘤细胞的抑制作用测定结果,研究并讨论了该肽结构与抗肿瘤活性的关系.

关 键 词:罂粟花粉  花粉肽  抗肿瘤活性  类似物  片段  

Studies on Synthesis,Structure and Antitumor Activities of Analogues of Papaver Somniferum Pollen Tridecapeptide
XU Jia-Xi,JIN Sheng. Studies on Synthesis,Structure and Antitumor Activities of Analogues of Papaver Somniferum Pollen Tridecapeptide[J]. Chemical Research In Chinese Universities, 1999, 20(5): 722-726
Authors:XU Jia-Xi  JIN Sheng
Affiliation:College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871
Abstract:Five analogues and five segments were designed and synthesized by using solid phase synthesis method according to separated papaver somniferum pollen tridecapeptide with antitumor activities as leading peptide. Their primary secondary structures in solution were determined by CD spectra and their inhibitive activities to human liver and mammary gland cancer cells were assayed by MTT method. The relationship of structure activity was studied and discussed.
Keywords:Papaver somniferum pollen   Pollen peptide   Antitumor activity   Analogue   Segment  
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