Molecular designing,structural elucidation,and comparison of the cleavage ability of oxovanadium(IV) Schiff base complexes |
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Authors: | N Raman S J Raja J Joseph J D Raja |
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Institution: | (1) Department of Chemistry, VHNSN College, Virudhunagar, 626001, India |
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Abstract: | Three novel oxovanadium(IV) Schiff base complexes VO(Phen)(L)]SO4, where L = 4(benzylidene)amino]antipyrine (Ia), 4(cinnamalidene)amino]antipyrine (Ib) and 4(2-chlorobenzylidene)amino]antipyrine
(Ic) are designed using benzaldehyde/cinnamaldehyde/2-chlorobenzaldehyde with 4-aminoantipyrine, 1,10-phenonthroline, and
vanadyl sulfate in the 1: 1: 1 molar ratio. They are synthesized by the template method. The geometry of the complexes is
elucidated by elemental analyses, IR, UV-Vis, ESR, CV, FAB mass, magnetic susceptibility, and conductance data. FAB mass spectrum
shows the degradation of the complexes. The electronic spectra of the complexes reveal their square pyramidal geometry in
which the ligands act as tetradentate. Their electrochemical parameters, the anodic and cathodic potentials, and the number
of electrons transferred are calculated. One quasi-reversible peak and one electron-transfer redox processes corresponding
to the formation of a VO(II)/VO(III) couple are observed. The antimicrobial activity of synthesized complexes are tested.
The results are compared with the standard penicillin. DNA cleavage experiments showed that Ia exhibits higher cleavage efficiency,
whereas Ib and Ic have the lower cleavage efficiency.
The text was submitted by the authors in English. |
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