Short and efficient total synthesis of fraxinellone limonoids using the stereoselective Oshima-Utimoto reaction |
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| Authors: | Trudeau Stéphane Morken James P |
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| Affiliation: | Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA. |
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| Abstract: | [reaction: see text] The catalytic diastereoselective Oshima-Utimoto reaction was employed for the construction of fraxinellone and related members of this limonoid family of natural products. After formation of the five-membered lactone, a stereoselective aldol reaction and olefin metathesis established the bicyclic ring system in the natural products. |
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