On the Synthesis of 3-Acetyl-1-aryl-1,4,5,6-tetrahydro-1<Emphasis Type="Italic">H</Emphasis>-1,2,4-triazepin-7-ones by Reaction of Nitrilimines with 3-Aminopropanoic Acid期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

On the Synthesis of 3-Acetyl-1-aryl-1,4,5,6-tetrahydro-1H-1,2,4-triazepin-7-ones by Reaction of Nitrilimines with 3-Aminopropanoic Acid

Authors:	Bassam?Abu Thaher,Jalal A.?Zahra,Mustafa M.?El-Abadelah,Hans-Hartwig?Otto author-information" > author-information__contact u-icon-before" > mailto:ottohh@pharmazie.uni-greifswald.de" title=" ottohh@pharmazie.uni-greifswald.de" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Chemistry Department, Faculty of Science, Islamic University of Gaza, Gaza Strip;(2) Chemistry Department, Faculty of Science, Jordan University, Amman, Jordan;(3) Department of Pharmaceutical/Medicinal Chemistry, University of Greifswald, DE-17487 Greifswald, Germany

Abstract:	Summary. Nitrilimines were prepared from N-arylhydrazono chlorides and reacted with -alanine yielding the corresponding amidrazones, which were treated with 1,1-carbonyldiimidazole in THF affording the hitherto unknown 3-acetyl-1-aryl-1,4,5,6-tetrahydro-1,2,4-triazepin-7-ones.

Keywords:	. Arylacetonitrilimines 1,2,4-Triazepin-7-ones Cyclization.
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