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A Convenient Synthesis of 2-Oxazolines and 2-Benoxazoles with PPh3-DDQ as the Dehydrating Reagent
Authors:Quancai Xu  Zhengning Li  Huiying Chen
Affiliation:1. College of Environmental and Chemical Engineering, Dalian University, Dalian, Liaoning 116622, China;2. Liaoning Key Laboratory of Bioorganic Chemistry, Dalian University, Dalian, Liaoning 116622, China;3. College of Life Science, Dalian Nationalities University, Dalian, Liaoning 116605, China
Abstract:2‐Oxazolines and 2‐benoxazoles were synthesized in high yields from acylamino alcohols and acylamino‐ phenols, respectively, with triphenylphosphine‐2,3‐dichloro‐5,6‐dicyanobenzoquinone (PPh3‐DDQ) as the dehydrating and activating reagent. The synthesis was accomplished under neutral conditions.
Keywords:oxazoline  benzoxazole  synthesis  dehydrative cylization  2,3‐dichloro‐5,6‐dicyanobenzoquinone  triphenylphosphine
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