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Preparation of 1,6‐naphthyridine‐2,5(1H,6H)‐diones |
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| Authors: | Tetsuo Ohta Hironori Fujisawa Mitsuru Kawazome Yasuto Nakai Isao Furukawa |
| Abstract: | Novel method for the synthesis of 3‐acyl‐1,6‐dialkyl‐7‐methyl‐1,6‐naphthyridine‐2,5(1H,6H)‐diones (2) was developed. The reaction of 2‐acyl‐1‐alkylamino‐1‐ethoxyethylenes (1) with acetyl chloride or β‐keto amide 3 with acetyl chloride in the presence of p‐toluenesulfonic acid gave 2 in moderate yield (14‐59% yield). |
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