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Pyridazines 92. Synthesis of dialkyldipyridazinodiazepinones as potential HIV‐1 reverse transcriptase inhibitors |
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| Authors: | Gottfried Heinisch Barbara Matuszczak Elisabeth Spielmann Myriam Witvrouw Christophe Pannecouque Erik De Clercq |
| Abstract: | Two methods for the preparation of dialkylsubstituted dipyridazino[4,3‐b:3′,4′‐e][1,4]diazepinones and dipyridazino[3,4‐b:3′,4′‐e][1,4]diazepinones are reported. The new compounds were evaluated for their inhibitory effects against the replication of human immunodeficiency virus [HIV‐1(IIIB) and HIV‐2(ROD)] in MT‐4 cells. |
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