Design and synthesis of anti-MRSA benzimidazolylbenzene-sulfonamides. QSAR studies for prediction of antibacterial activity |
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| Authors: | González-Chávez Marco Martín Méndez Francisco Martínez Roberto Pérez-González Cuaúhtemoc Martínez-Gutiérrez Fidel |
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| Institution: | Programa de Doctorado en Ciencias Biológicas, Universidad Autónoma Metropolitana, México DF, Mexico. |
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| Abstract: | A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds. |
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