Synthetic Route to Ergot Alkaloids |
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Authors: | Istv n Moldvai,Eszter Temesv ri‐Major,M ria Incze,G bor D rnyei, va Szentirmay,Csaba Sz ntay |
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Affiliation: | István Moldvai,Eszter Temesvári‐Major,Mária Incze,Gábor Dörnyei,Éva Szentirmay,Csaba Szántay |
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Abstract: | Rye is sometimes infected by a fungus called Claviceps purpurea. The term ergot designates the dark, brown, tuberous bodies which can be collected before or during harvesting and represent one of the most remarkable drugs of our therapeutic arsenal. Actually, the most significant alkaloids are metabolic products of these fungi. We elaborated three alternative total synthetic pathways to construct the ergoline skeleton, one of which – suitable for scaling up – finally resulted in (+)‐lysergic acid ( 32a ) and α‐ergocryptine ( 1 ) (Schemes 5 and 6). |
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