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Two Novel Olean Triterpenoids from Celastrus hypoleucus
Authors:Kui‐wu Wang  Hong‐xiang Sun  Bin Wu  Yuan‐jiang Pan
Abstract:Two new triterpenoids, (3β)‐olean‐12‐ene‐3,23‐diol ( 1 ) and (6α)‐6‐hydroxyolean‐12‐en‐3‐one ( 2 ) were isolated from the MeOH extract of the stalks of Celastrus hypoleucus (Oliv .) Warb ., together with the seven known compounds (3β,22α)‐3,22‐dihydroxyolean‐12‐en‐29‐oic acid, β‐amyrin and β‐amyrin palmitate, wilforlide A, wilforilide B, palmitic acid, and β‐sitosterol. Their structures were elucidated on the basis of spectroscopic data and, in the case of 2 , by X‐ray crystallography. Compound 1 showed moderate cytotoxicity against human cervical squamous carcinoma (Hela) cells.
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