|
|||||
|
|
Formal Synthesis of (±)‐Isodihydronepetalactone |
|
| Authors: | Meng‐Yang Chang Bo‐Rm Chang Chung‐Ho Chang Shui‐Tein Chen Nein‐Chen Chang |
| Abstract: | A formal synthesis of (±)‐isodihydronepetalactone ( 1 ) from cyclobutenone 5 was de scribed. Baeyer‐Villiger lactonization of cyclobutanone 8 followed by decholorination led to lactone 4 , which under went a series of functional group trans formations, furnished cyclopentanone derivative 15 . Shapiro reaction on hydrazone derivative in the presence of excess dry ice gave lactone 2 . Lactone 2 had previously been converted to isodihydronepetalactone ( 1 ). |
| Keywords: | Isodihydronepetalactone Monoterpenoid [2+2] Cycloaddition Shapiro reaction |