Studies on pyrrolidinones: Some attempts to improve the synthesis of methyl n‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (hei 81) by using n‐acyl iminium salts methodologies |
| |
| Authors: | Anne Bourry,Franck Pitard,Benoî t Rigo,G arard Sanz,Fabrice Camus,Bernadette Norberg,Fran lois Durant,Daniel Couturier |
| |
| Affiliation: | Anne Bourry,Franck Pitard,Benoît Rigo,Géarard Sanz,Fabrice Camus,Bernadette Norberg,Françlois Durant,Daniel Couturier |
| |
| Abstract: | Some ways to use the N‐acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl N‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3‐(3,4,5‐trimethoxyphenyl)dihydropy‐rrolo[1,2‐c]oxazole‐1,5‐dione). |
| |
| Keywords: | |
|
|
