Abstract: | A practical method for large‐scale preparation of acid‐labile aglycones including protopanaxadiol, protopanaxatriol, cycloastragenol, and jujubogenin from the corresponding glycoside containing fraction was developed. The key point of this improved method is to generate and maintain the critical reaction conditions, anhydrous and strongly basic, in situ. This effort over comes the weakness of the reported method for oxidative cleavage of glycones and scales up the preparation of these acid‐labile aglycones for further studies. |